The top models in the series - the S5 as Sportback, Coupé and Cabriolet - have also been refreshed. All S5 models, including the Coupé, are now equipped with the 3.0 TFSI producing 245 kW (333 hp). Compared to the 4.2-liter V8 it replaces in the Coupé, the supercharged V6 consumes on average 20 percent less fuel per 100 kilometers. Average fuel consumption is just 8.1 liters (29.04 US mpg) while performance remains impressive. The S5 Coupé accelerates from 0 to 100 km/h (62.14 mph) in just 4.9 seconds on its way to an electronically governed top speed of 250 km/h (155.34 mph).

Visual cues to the updated S models include new lights, modified body details and new crystal-effect paint finishes. Subtle changes can also be found in the interior. The most important technical updates for the Audi S5 are quattro drive with the crown-gear center differential and electromechanical power steering. The special S sport suspension and the standard 18-inch wheels deliver the power to the road.